normal blood uric acid levels - Gout - related or not to hyperuricemia?
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Gout - related or not to hyperuricemia?

Gout is a health problem resulting because of the deposit of uric acid crystals in the joints and surrounding tissues. It is characterized by an excess of uric acid in the body that deposits in different parts of the body leading to recurring attacks of joint inflammation. We know two types of gout: acute and chronic. The most severe phase of gout is chronic gout that beside joint inflammation and pain may also lead to kidney malfunction and kidney stones.


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WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

Not everyone who has gout will experience such severe symptoms. Some patients may only develop elevated blood uric acid levels, a condition that is known as hyperuricemia. These patients may not have the arthritic joint pain and other symptoms. The actual term "gout" is often used in reference to the painful joint attacks.

Gout is also known as gouty arthritis and it' s cause is the accumulation of uric acid that then turns into crystals. These crystals are found in your joints. Gout is a very painful disease that mostly affects a single joint, usually your big toe. The gout patient usually suffers from this much pain because there are two pain sources: one is the crystals that are found in the joint ans if the affected area is somehow moved, pain is very big and the second reason why a gout case is so painful is because of inflammation. The tissues that surround your joint get inflamed and they hurt very much at the slightest touch. This is the reason why a gout case is so painful.

Gout attacks sometimes happen without a specific cause, but sometimes the actual causes of a gout attack are known. If a person is overweight, if a person eats meats that are high in purines , if they take medication, such as aspirin or diuretics and if they consume too much alcohol then these factors can cause an attack of gout.

The main cause of gout is the level of uric acid that you have in your blood. However, there are also many exceptions. People who despite the high level of uric acid in his/ her blood never develop gout. It is a common belief that genes are also another gout cause. This disease is inherited.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Gout has the distinction of being one of the most recorded medical illnesses throughout history. It is also said to be related to an inherited abnormality in the ability for the body to process uric acid. Uric acid is a break-down of pureness that is part of the many foods frequently consumed. This inability to process uric acid can cause the painful attacks of gout, along with the other serious conditions mentioned above.

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

Specialists are able to advice humans how to prevent gouty arthritis. Obesity in youth, high alcohol intake and unhealthy diets may lead to gout attacks. Also aspirin and diuretics could be a cause for developing gout attacks. Of course injury of the joints could lead to a gout attack. Gout attacks are also related to some diseases such as leukemia, lymphoma and hemoglobin disorders.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

As a result, patients with gout can experience decreased kidney function and kidney stones, which are also very painful. When these problems occur, they must be treated immediately.

Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

The most common affection is the big toe joint problem. It is seen in about 50 % of the cases of gout. Other joints can be affected too. The ankles, the knees, wrists, fingers and elbows are at risk. After a rapid onset of the pain in the affected joint it usually follows warmth, swelling and high sensitivity for the joint. These painful attacks may last hours to days and may be recurrent.

While hyperuricemia and gout often occur together, there is currently not medical evidence that shows their exact relationship. Some patients with hyperuricemia do not develop gout, while others with repeated gout attacks show normal or low blood uric acid levels. Still, it continues to be a common problem, and should be treated to keep other more serious conditions from occurring. Because it is painful, and, therefore, very distinguishable, it can usually be easily diagnosed and quickly treated.

Throughout history it is believed that gout is the most frequent illness. It is also believed that gout is a problem that can be inherited. It consists of the deposit of uric acid in the joints or surrounding tissues. Abnormal elimination of uric acid can cause attacks of painful arthritis (gout attack), kidney stones or even kidney failure. Even so there are known a few cases where patients only develop elevated blood uric acid levels (hyperuricemia) without developing arthritis or kidney problems.

 
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It is believed that a relation between gout and hyperuricemia exists but it is unclear. We are certain that many patients with hyperuricemia do not develop gout. We are also certain about the fact that some patients with repeated gout attack have normal or low blood uric acid levels. About 10 percent of the male population has hyperuricemia and a small percentage of them will actually develop gout.

Gout attack means a rapid onset of joint inflammation and pain that usually occur over night. A high number of persons develop gout. Only in America not less than one million people are suffering from recurrent gout attacks. It is well to know that men are more prone to develop gout than women. It is believed that gout is nine times more common in men than in women. Men are prone to develop gout right after puberty while women are at risk only at menopause.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

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One of the most common problems that can be associated with gout and kidney function is blockage of these organs. This blockage occurs in the tubular filters that allow the kidneys to rid the body of unwanted materials. When they become clogged with uric acid crystals, the kidneys are unable to perform their proper function. When this happens, kidney failure can occur. This condition must be treated right away in order to restore proper function to the kidneys, and to the body.

At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.

Gout is a condition that results when crystals of uric acid are deposited body tissues, and is characterized by an overload of this acid. It causes joints to become inflamed and is often very painful. Chronic gout can lead to deposits of hard lumps in and around the joints.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

Even if gout can appear in both men and women, the first signs of a gout are mostly seen in men that are over forty.

If you are intersted in finding more information about gout you can click on this website http://www.gout-info-center.com. Also you will find there valuable information about gout diet and Foods That Cause Gout.

For more information about gout diet please review http://www.gout-info-center.com/causes-of-gout.htm or even http://www.gout-info-center.com/gout-symptoms.htm

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

Gout, when referred to in this way, is usually an extremely painful arthritic attack with a rapid onset of joint inflammation. The deposits of uric acid crystals in the joint fluid that helps to facilitate proper motion precipitate this inflammation. When this occurs, this fluid is unable to correctly do its job because the crystals are in the way. Because of this, the joints are not able to move properly, and movement becomes very painful.

Gout is one of the most old arthritis forms. Men are mainly affected by gout. Besides the fact that gout is more common in men than women, old studies confirmed by new ones prove that women, if they do develop gout, they only suffer from this disease if they have reached menopause. If a woman has not yet reached menopause, then the chances are she will not develop gout. Other studies on gout patients have shown that this condition mostly affects people who have good financial conditions. Furthermore, gout patients are said to be very intelligent. Some time ago gout was considered to be the wealthy' s disease, because they eating and drinking habits were believed to cause gout. However, recent studies have shown something different. Although rich foods and alcohol are related to gout, they can only cause a gout attack, but they are not the cause of gout.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

John Mepham has lost track of the number of hours he has spent researching gout treatments. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment at www.gout-smashers-guide.com It's an e-book with an emphasis on natural gout treatment


 
 
     
 
 





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