allopurinol 300 mg - A New Gout Drug. Febuxostat wins marketing approval in the European Union
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A New Gout Drug. Febuxostat wins marketing approval in the European Union

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.


At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.


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 Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

General Description Triphala literally means 'three fruits' (tri = three, phala = fruits). It is a mixture composed of the three essential myrobalans. They are:-

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

Most people do not realize the simplicity in natural holistic treatments (treating the whole body as opposed to one area of the body). Understanding that natural treatments are a way to treat the ailment by treating the whole body is the cornerstone of natural health.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

(vi) Obesity Amalaki is especially known to disintegrate the fatty accumulation in the body. Thus, Triphala can reduce the excess weight in obese people. In addition, regular use of the Triphala can also heal several of the complications of obesity. Since Triphala can dissolve the serum cholesterol, it decreases the chances of cardiovascular problems. The acrid and bitter components of Triphala are also good in the treatment and control of diabetes mellitus, to which obese people are much prone.

A Gout Natural Treatment that Works! Only in the last few decades, have developed countries relied completely upon doctors and drugs for their health. However, simple remedies that worked over 100 years ago still work today. Yet, doctors won't even consider the legitimacy of natural remedies that work. Consequently, doctors continue to prescribe side-effect laden medications for all ailments.

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

From obesity, we move to related causes of gout, specifically dietary and food habits. There are many types of food that have large amounts of purines, or substances that play a large role in uric acid production. It's kind of disturbing to find out that most foods that are rich in protein and fat also have a high purine content. But in today's fast-paced mode of life, this is just the kind of food that we're accustomed to eating! To further reduce the risk of acquiring gout, one should also refrain from taking in too much organ meats or sweetbread (including heart, kidney, and liver delicacies). Some seafoods, such as scallops, mackerel, and mussels are also dietary no-no's because these too are rich in purines. Intake of high-fat dairy foods should also be curtailed, including comfort foods like ice cream, butter, and cheese.

NSAIDs can cause side-effects including stomach pain, bleeding and ulcers. And corticosteroid (prednisone) can cause more serious side-effects including thinning of bones, poor wound healing and decreased ability to fight infection. It would be recommended to avoid corticosteroid because of severity of the side-effects.

Precautions Triphala does not have any major side-effects. But it must be avoided by pregnant woman. People having complaints of diarrhea and dysentery must also restrict the use of Triphala.

(iii) Haritaki is one of the mildest and safest laxatives used in Ayurvedic medicine. It prevents blood clotting. Haritaki is a stomachic; it improves the functioning of the stomach and facilitates digestion. Haritaki is used to improve all nutritional imbalances in the system, and looks after the entire digestive, absorptive, assimilative and excretory process.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

Though scientists are as yet uncertain about how gout really occurs, they have discovered that the causes of gout can be genetic or environmental in nature, as discussed above. Knowing the things and events that can cause the disease would be a big step in reducing one's risk of acquiring it.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

The following are the general properties of Triphala:- (i) Triphala has anti-inflammatory properties. (ii) Triphala regulates the functioning of the cardiovascular system and the liver. (iii) Triphala has excellent effect on the digestive system. It has laxative properties. (iv) Triphala can reduce the cholesterol that is accumulated in the blood. (v) Triphala is an expectorant. (vi) Triphala fastens the healing process, because it has collagen, an important cementing material required in the process of blood clotting.

If you are asking these questions, you are the perfect candidate to try a 100% guaranteed (yes, guaranteed to work) natural gout treatment you can use at home. Take a minute and visit our Gout Natural Treatment Website and see why thousands of gout sufferers are going natural! You will be astonished how simple, affordable and guaranteed our natural gout treatment is.

Gout can also be caused by certain medications, such as thiazide diuretic drugs, which are prescribed for heart failure and hypertension. Figures show that the majority of people who use this kind of drug acquired gout later in life. Other drugs that may contribute to a higher risk for gout are immunosuppressants (such as cyclosporine), low doses of aspirin, and pyrazinamide, an anti-tuberculosis agent. Gout is also strangely related to organ transplantation. Heart and liver transplants can heighten the risk, but perhaps it's a kidney transplant that poses the greater risk, since renal problems can prevent the elimination of uric acid from the body.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

Do Natural Treatments Work? If you knew that a natural treatment was effective and worked; would you use it? Of course you would! It would be easier on your body and your pocketbook. But why don't doctors tell us about simple, effective natural treatments? Consider why the pharmaceutical industry in a multi-billion dollar industry? Consider why medications are pennies across the border compared to hundreds of dollars in developed countries? Consider why pharmacists get paid 6 digits for dispensing pills? Consider why the family doctor gets paid more than your state governor?

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

The Truth about Gout Medical Treatment What's in store for those who decide to treat gout medically? Typically, there are two treatments prescribed by doctors to remedy the pain associated with gout. They are nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroid drugs injected to arthritic area. Both treatments will typically stop the pain with some side-effects.

(i) Amalaki, i.e. the Indian gooseberry, is the richest source of vitamin C in the world. It is a light green fruit with a sour taste due to its acidic content. The fruit is cooling and refreshing. It also has laxative and purgative properties. Since it has good amount of vitamin C, amalaki hastens blood clotting and heals wounds. In some cases, amalaki has been used to renew lost sexual vigor in men and women with success.

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

The final natural health misunderstanding deals with traditional medical treatments. Many natural health experts are not opposed to medication and surgery. In reality, the medical field has helped millions of people annually. However, the problem arises from the excessive amounts of medications prescribed for some of the simplest ailments. Did you know that hundreds of antibiotics are dubbed useless because of resilient ailments? We are literally allowing doctors to take care of our body instead of our natural immunity!

 
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A condition called hyperuricemia is one of the causes of gout. This is when the body fails to eliminate excess amounts of uric acid. Some people are born with a genetic metabolic defect in which they not only produce extra uric acid, but they fail to excrete it efficiently as well. This is bad because excessive amounts of uric acid will lead to the formation of uric crystals, which will then become embedded in the joints and the tissue surrounding them. These crystals are also known as tophi, and they are the cause of joint inflammation and pain. Gout usually appears in the joint of the big toe, but it can also become manifest in joints in the ankles, feet, knees, wrists, hands, and elbows. Pictures of a gouty toe almost always show the same characteristics: swelling and redness, and as you can probably imagine, pain.

(iv) Liver Disorders Triphala helps in the proper functioning of the liver and the pancreas. It regulates the bile duct and treats sluggishness of the liver. Triphala is a support to the liver in performing most of its physiological functions. It is a common medicine prescribed to patients of hepatitis.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

(ii) Bibhitaki is a bitter herb, also popularly known as behra. Like amalaki, it also has beneficial effects in healing of wounds. It is a tonic and a laxative. It can reduce fevers, and hence it is an antipyretic.

(v) Nervous Disorders Triphala is prescribed in nervous problems like the Alzheimer's due to its cooling and toning properties. It can repair the degenerated nerves and bring the nervous system back to a normal state of functioning.

The Truth about Natural Health Natural health has been the newest rave in health and medical communities in recent years. Why? Because natural health is considerably effective at treating numerous ailments and it allows YOU to take care of your health and NOT a doctor or pharmacy. However, millions of people still believe that natural treatments are 'quacks'. To the sufferers' demise, many people have opted to not even consider a natural treatment for their health because of this stigma.

(iii) Gout Due to its anti-inflammatory properties, Triphala is used in the treatment of gout and other joint problems. Gout is formed when excess uric acid deposits in the joints of the bones. This is removed by Triphala, which gets it expelled through urination. Therefore, the conditions of gout are brought to a minimum.

Uses Triphala is vastly considered as one of the most important medicines Ayurveda has ever provided to the world. The following are the uses for which Triphala is today internationally acclaimed:-

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Think about this... Does modern medicine want you to know about proven natural remedies that work? Does your doctor want you to know about a proven, guaranteed gout natural treatment?

It's time you treat your gout! As you consider the possibilities for gout treatments, it is always important to know all of your options. Two options for gout sufferers are the traditional medical treatment of medication and injections and the more recently popular gout natural treatment. Both treatments will eliminate the arthritic pain (typically affecting the big toe), but only one is remarkably simpler, more affordable and more effective. In fact, the gout natural treatment not only stops the pain; the simple remedy also cures the cause over time so the gout sufferer no longer has to worry about more attacks!

(i) Amalaki (Emblica officinalis) (ii) Bibhitaki (Terminalia belerica) (iii) Haritaki (Terminalia chebula) Properties The properties of the Triphala are dependent on the properties of its individual herbs. Let us see what these properties are:-

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It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

Gout is certainly not a fun condition to have. It's a common rheumatic disease and it counts rheumatoid arthritis and osteoarthritis among its close cousins. Figures show that some 840 people out of 100,000 are afflicted with this disease, most of them men. Just what are the causes of gout, and are there any effective ways to avoid it? More often than not, gout is a result of lifestyle choices, but there are other factors that contribute to the disease's occurrence.

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But what will work? Every gout sufferer just wants a treatment that will cure their gout. What treatment is the most effective? What treatment is affordable? What treatment is the simplest?

Alcoholic beverages should strictly be avoided or at least restricted to an occasional glass or two. This is because alcohol has a high purine concentration and contributes in significant ways to the body's production of uric acid. Not only does it spur the body on to produce more uric acid, but it also affects the ability of the kidneys to flush out excess amounts of this substance. Plus, alcohol is fattening, and we know that surplus weight can also lead to gout.

A number of health problems have been shown to lead to gout. Certain cancers or diseases involving blood-manufacturing organs are specifically cited, such as lymphoma and leukemia. A skin disease called psoriasis has likewise been linked to the emergence of gout in a number of people. And over-exposure to lead does not only cause birth defects and blood poisoning, it can lead to gout as well. Another all too common health problem among many people, especially those in the West, is obesity. Being overweight can cause not only gout, but other diseases as well, including diabetes, hypertension, and other forms of arthritis.

(i) Digestive Problems All the three constituents of the Triphala have laxative properties. Triphala can stimulate the mucosal lining of the gastric and the intestinal tract, and hence help in digestion. Triphala is prescribed to people having constipation problems. By regular use of Triphala for a few days, the toxins within the intestinal tract are flushed out. Triphala is also prescribed for tonifying (i.e. regulating) the functioning of the stomach and the colon. Triphala is prescribed as an essential medicine for the elderly who are prone to have more digestive problems than the younger people. This is mainly because Triphala is a non-habit forming drug, and it has no known side-effects even after prolonged use.

(vii) Ocular Problems Triphala has beneficial effects in the treatment of eye infections like conjunctivitis and visual problems like cataract and glaucoma. On a lighter note, Triphala is prescribed to treat eye problems such as fatigue, redness and soreness of the eyes. It is used as eyewash in these cases.

For instance, think of the flu! How does your body feel when you have the flu? Exactly, it hurts all over. The whole body is working together as one organism that is affected by all its parts. Natural treatment remedies work by giving the body the proper means to heal the ailment. In the case of gout, various fruits, vitamins and a cooking ingredient act to neutralize the uric acid that causes current and future gout attacks. Along with curing the pain, the water soluble fiber from the fruit also cause the body to flush itself naturally. Leaving your whole body to benefit from the gout natural treatment.

(ii) Flatulence Triphala is prescribed to people who have excess acidity in their stomachs. A regular use of the Triphala helps to dissolve all the toxic acids in the stomach. This helps in the treatment of flatulence.

Read more about the benefits of Triphala. Also find Herbal Colon Cleansing at http://www.ayurvediccure.com - World's Finest Portal on Ayurveda and Ayurvedic Treatments


 
 
     
 
 





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